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| Registros recuperados : 21 | |
| 2. |  | CAMPAGNANI, M. O.; CAMPOS, W. G.; AMORIM, S. S.; ROSA, L. H.; AUAD, A. M.; MAURÍCIO, M. Bioprospecção de fungos entomopatogênicos associados à Mahanarva spectabilis na Amazônia In: CONGRESSO BRASILEIRO DE MICOLOGIA, 8., 2016, Florianópolis. Anais... São Paulo: Sociedade Brasileira de Micologia, 2016.| Biblioteca(s): Embrapa Gado de Leite. |
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| 3. | | ROSA, L. H.; QUEIROZ, S. C. do N. de; WANG, X.; TECHEN, N.; CANTRELL, C. L.; WEDGE, D. E. Antifungal fatty acids produced by Coniochaeta ligniaria: a cryptic endophytic fungus associated with Smallanthus sonchifolius' autotrophic cultures. In: Planta Medica, Dordrecht, v. 79, n. 5, p. 5, 2013. Abstracts of the 12th International Conference on the Science of Botanicals (ICBS), Oxford, 2013.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 5. | | GONÇALVES, V. N.; CAMPOS, L. S.; MELO, I. S. de; PELLIZARI, V. H.; ROSA, C. A.; ROSA, L. H. Penicillium solitum: a mesophilic, psychrotolerant fungus present in marine sediments from Antarctica. Polar Biology, v. 36, n. 12, p. 1823-1831, 2013.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 6. | | MELO, I. S. de; VASCONCELLOS, R. L. F.; NASCIMENTO, R. dos S.; VILELA, E. S. D.; KAVAMURA, V. N.; ROSA, L. H. Endophytic bacteria from Deschampsia antarctica and assessment of their potential to promote plant growth. In: INTERNATIONAL SYMPOSIUM ON MICROBIAL ECOLOGY, 15., 2014, Seoul. Proceedings... Wageningen: The International Society for Microbial Ecology (ISME), 2014. p. 139-140.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 7. | | ROSA, L. H.; QUEIROZ, S. C. do N. de; MORAES, R. M.; WANG, X.; TECHEN, N.; PAN, Z.; CANTRELL, C. L.; WEDGE, D. E. Coniochaeta ligniaria: antifungal activity of the cryptic endophytic fungus associated with autotrophic tissue cultures of the medicinal plant Smallanthus sonchifolius (Asteraceae). Symbiosis, Philadelphia, v. 60, p. 133-142, 2013.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 8. | | MELO, I. S. de; VILELA, E. S. D.; PARMA, M. M.; NASCIMENTO, R. dos S.; ROSA, L. H.; PELLIZARI, V. H. Bactérias celulolíticas isoladas do lago Stenhouse na Península Antártica. In: WORKSHOP DE BIODEGRADAÇÃO E BIORREMEDIAÇÃO, 3., 2009, Campinas. Anais... Jaguariúna: Embrapa Meio Ambiente, 2009. 1 CD-ROM.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 9. | | MENDONÇA, M. C. de; AUAD, A. M.; MADUREIRA, A. P.; MAURÍCIO, R. M.; SILVA, N. B. N.; SILVA, A. C. C. R.; ROSA, L. H.; CAMPOS, W. G. Inoculação endofítica de fungos entomopatogênicos em Brassica oleracea var. acephala L. para o controle biológico de Plutella xylostella (Lepdoptera) e Brevicoryne brassicae (Hemiptera). In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu. Resumos. São Paulo: Sociedade Brasileira de Microbiologia, 2023.| Biblioteca(s): Embrapa Gado de Leite. |
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| 10. | | MELO, I. S. de; SANTOS, S. N.; ROSA, L. H.; PARMA, M. M.; SILVA, L. J.; QUEIROZ, S. C. do N. de; PELLIZARI, V. H. Isolation and biological activities of an endophytic Mortierella alpina strain from the Antarctic moss Schistidium antarctici. Extremophiles, Tokyo, v. 18, n. 1, p. 15-23, 2014.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 11. | | MELO, I. S. de; ZUCCHI, T. D.; SILVA, R. E. da; VILELA, E. S. D.; SÁBER, M. L.; ROSA, L. H.; PELLIZARI, V. H. Isolation and characterization of cellulolytic bacteria from the Stain house Lake, Antarctica. Folia Microbiologica, Prague, v. 59, p. 303-306, 2014.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 12. | | CAMPAGNANI, M. O.; CAMPOS, W. G.; AMORIM, S. S.; ROSA, L. H.; AUAD, A. M.; CANGUSSÚ, M. A.; MAURÍCIO, R. M. Prospection and fungal virulence associated with Mahanarva spectabilis (Hemiptera: Cercopidae) in an Amazon silvopastoral system. Florida Entomologist, v. 100, n. 2, p. 426-432, 2017.| Biblioteca(s): Embrapa Gado de Leite. |
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| 13. | | SILVA, L. J. da; SOUZA, D. T.; GENUÁRIO, D. B.; VARGAS-HOYOS, H. A.; SANTOS, S. N.; ROSA, L. H.; ZUCCHI, T. D.; MELO, I. S. de. Rhodococcus psychrotolerans sp. nov., isolated from rhizosphere of Deschampsia antarctica. Antonie van Leeuwenhoek, v. 111, n. 4, p. 629-636, 2018.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 14. | | CAMPAGNANI, M. O.; MADUREIRA, A. P.; VIANA, J. P. R.; AMORIM, S. S.; ROSA, L. H.; AUAD, A. M.; CANGUSSU, M. A.; MAURICIO, R. M.; CAMPOS, W. G. Virulência em lagartas (lepidoptera) de novos fungos entomopatogênicos isolados de Mahanarva spectabilis (Distant) (Hemiptera: Cercopidae). In: SIMPÓSIO DE MICROBIOLOGIA DA UFMG, 5., 2018, Belo Horizonte. Resumos... Belo Horizonte: Universidade Federal de Minas Gerais, 2018. p. 93.| Biblioteca(s): Embrapa Gado de Leite. |
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| 15. | | CAMPAGNANI, M. O.; MADUREIRA, A. P.; OLIVEIRA, M. M. B.; MAGALHÃES SILVA, N. B.; RIOS SILVA, A. C.; COELHO, L. C.; ROSA, L. H.; AUAD, A. M.; CANGUSSÚ, M. A.; MAURÍCIO, R. M.; CAMPOS, W. G. Eficiência de fungos entomopatogênicos contra Mahanarva spectabilis (distant) (hemiptera: cercopidae) a campo. In: SIMPÓSIO DE MICROBIOLOGIA DA UFMG, 5., 2018, Belo Horizonte. Resumos... Belo Horizonte: Universidade Federal de Minas Gerais, 2018. p. 94.| Biblioteca(s): Embrapa Gado de Leite. |
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| 16. | | MENDONÇA, M. C. de; AUAD, A. M.; MADUREIRA, A. P.; MAURÍCIO, R. M.; CANGUSSU, M.; ROSA, L. H.; PEREIRA, M. F.; MUNIZ, M.; SOUZA, S. R. O.; SILVA, A. C. R.; SILVA, N. B. N.; CAMPOS, W. G. Eficiência de fungos isolados em sistema silvipastoril no controle biológico de Mahanarva spectabilis (hemiptera: cercopidae) em condições de campo. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 32., 2023, Foz do Iguaçu. Resumos. São Paulo: Sociedade Brasileira de Microbiologia, 2023.| Biblioteca(s): Embrapa Gado de Leite. |
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| 17. | | OKI, Y.; GOTO, B. T.; JOBIM, K.; ROSA, L. H.; FERREIRA, M. C.; COUTINHO, E. S.; XAVIER, J. H. de A.; CARVALHO, F.; MOREIRA, F. M. de S.; SOUZA, F. A. de; BERBARA, R. L. L.; FERNANDES, G. W. Arbuscular mycorrhiza and endophytic fungi in ruspestrian grasslands. In: FERNANDES, G. W. (Ed.). Ecology and conservation of mountaintop grasslands in Brazil. Switzerland: Springer International Publishing, 2016. cap. 8, p. 157-179.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 18. | | SILVA, L. J. da; CREVELIN, E. J.; SOUZA, D. T.; LACERDA JÚNIOR, G. V.; OLIVEIRA, V. M.; RUIZ, A. L. T. G.; ROSA, L. H.; MORAES, L. A. B.; MELO, I. S. de. Actinobacteria from Antarctica as a source for anticancer discovery. Scientific Reports, v. 10, article 13870, 2020. p. 1-15.| Biblioteca(s): Embrapa Meio Ambiente. |
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| 19. | | CARVALHO, C. R. de; MAIA, M. Q.; SOBRAL, M.; PEREIRA, G. M. D.; SILVA, K. da; VITAL, M. J. S.; ZILLI, J. E.; ROSA, C. A.; ROSA, L. H. Diversity and antimicrobial activity of culturable endophytic fungi associated with the neotropical ethnomedicinal plants Copaifera langsdorffii and Copaifera pubiflora South African Journal of Botany, v. 142, p. 305-315, Nov. 2021. 11 p.| Biblioteca(s): Embrapa Agrobiologia; Embrapa Florestas. |
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| 20. | | CARVALHO, C. R. de; MAIA, M. Q.; SOBRAL, M.; PEREIRA, G. M. D.; SILVA, K. da; VITL, M. J. S.; ZILLI, J. E.; ROSA, C. A.; ROSA, L. H. Diversity and antimicrobial activity of culturable endophytic fungi associated with the neotropical ethnomedicinal plants Copaifera langsdorffii and Copaifera pubiflora. South African Journal of Botany, v. 142, p. 305-331, November 2021.| Biblioteca(s): Embrapa Agrobiologia. |
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| Registros recuperados : 21 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
29/12/2020 |
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Data da última atualização: |
29/12/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SILVA, L. J. da; CREVELIN, E. J.; SOUZA, D. T.; LACERDA JÚNIOR, G. V.; OLIVEIRA, V. M.; RUIZ, A. L. T. G.; ROSA, L. H.; MORAES, L. A. B.; MELO, I. S. de. |
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Afiliação: |
LEONARDO JOSÉ SILVA, ESALQ-USP; EDUARDO JOSÉ CREVELIN, FFCLRP-USP; DANILO TOSTA SOUZA, FFCLRP-USP; GILENO VIEIRA LACERDA JÚNIOR; VALERIA MAIA DE OLIVEIRA, CPQBA-UNICAMP; ANA LUCIA TASCA GOIS RUIZ, FCF-UNICAMP; LUIZ HENRIQUE ROSA, UFMG; LUIZ ALBERTO BERALDO MORAES, FFCLRP-USP; ITAMAR SOARES DE MELO, CNPMA. |
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Título: |
Actinobacteria from Antarctica as a source for anticancer discovery. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Scientific Reports, v. 10, article 13870, 2020. |
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Páginas: |
p. 1-15. |
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ISSN: |
2045-2322 |
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DOI: |
https://doi.org/10.1038/s41598-020-69786-2 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7), glioblastoma (U251), lung/non-small (NCI-H460) and kidney (786-0) human cancer cell lines. Cinerubin B and actinomycin V were the predominant compounds identified in Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653, respectively. Our results suggest that the rhizosphere of D. antarctica represents a prominent reservoir of bioactive actinobacteria strains and reveals it as an important environment for potential antitumour agents. MenosAbstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7)... Mostrar Tudo |
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Palavras-Chave: |
Anticancer activity; Antitumoral activity. |
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Thesagro: |
Bactéria não Patogênica; Câncer. |
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Thesaurus NAL: |
Actinobacteria; Antarctica. |
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Categoria do assunto: |
S Ciências Biológicas |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/219757/1/Melo-Actinobacteria-Antarctica-2020.pdf
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Marc: |
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008 2020 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $ahttps://doi.org/10.1038/s41598-020-69786-2$2DOI
100 1 $aSILVA, L. J. da
245 $aActinobacteria from Antarctica as a source for anticancer discovery.$h[electronic resource]
260 $c2020
300 $ap. 1-15.
520 $aAbstract: Although many advances have been achieved to treat aggressive tumours, cancer remains a leading cause of death and a public health problem worldwide. Among the main approaches for the discovery of new bioactive agents, the prospect of microbial secondary metabolites represents an effective source for the development of drug leads. In this study, we investigated the actinobacterial diversity associated with an endemic Antarctic species, Deschampsia antarctica, by integrated culture-dependent and culture-independent methods and acknowledged this niche as a reservoir of bioactive strains for the production of antitumour compounds. The 16S rRNA-based analysis showed the predominance of the Actinomycetales order, a well-known group of bioactive metabolite producers belonging to the Actinobacteria phylum. Cultivation techniques were applied, and 72 psychrotolerant Actinobacteria strains belonging to the genera Actinoplanes, Arthrobacter, Kribbella, Mycobacterium, Nocardia, Pilimelia, Pseudarthrobacter, Rhodococcus, Streptacidiphilus, Streptomyces and Tsukamurella were identified. The secondary metabolites were screened, and 17 isolates were identified as promising antitumour compound producers. However, the bio-guided assay showed a pronounced antiproliferative activity for the crude extracts of Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653. The TGI and LC50 values revealed the potential of these natural products to control the proliferation of breast (MCF-7), glioblastoma (U251), lung/non-small (NCI-H460) and kidney (786-0) human cancer cell lines. Cinerubin B and actinomycin V were the predominant compounds identified in Streptomyces sp. CMAA 1527 and Streptomyces sp. CMAA 1653, respectively. Our results suggest that the rhizosphere of D. antarctica represents a prominent reservoir of bioactive actinobacteria strains and reveals it as an important environment for potential antitumour agents.
650 $aActinobacteria
650 $aAntarctica
650 $aBactéria não Patogênica
650 $aCâncer
653 $aAnticancer activity
653 $aAntitumoral activity
700 1 $aCREVELIN, E. J.
700 1 $aSOUZA, D. T.
700 1 $aLACERDA JÚNIOR, G. V.
700 1 $aOLIVEIRA, V. M.
700 1 $aRUIZ, A. L. T. G.
700 1 $aROSA, L. H.
700 1 $aMORAES, L. A. B.
700 1 $aMELO, I. S. de
773 $tScientific Reports$gv. 10, article 13870, 2020.
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Embrapa Meio Ambiente (CNPMA) |
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